I did all the quests solo with a Mezoar Truebow.
Definitely help the Spireguard! It's just the right thing to do.
I've been playing since right after the Kickstarter and have a bunch of characters in parties, but I created a new guy and wanted to see how all the quests worked on my own. The the lady with the bone arm and the final dungeon were the hardest to beat for a not-magic-having sort, but the treasure and utility items really, really helped me live through it. I really enjoyed the writing throughout, though there is a very dicey moment in the Earthwarden quest when you must choose not to trust a NPC who has been helping you thus far.
I especially like the way gender is handled in the game - tons of women in the NPCs, female character designs aren't "sexy mezoars", etc., and I love how so far everyone I've played with has been cool.
Here's my character's info:
Revelation (got this only at the end, still figuring out its usefulness)
Study the Situation
Heroic Calling (this is the BEST, would not have made it without it)
Extinguish (wish I'd gotten these much earlier, definitely help the Spireguard boys and girls)
Flood the Mind (this never did anything particularly useful for me, will probably get rid of it next respec)
Find the Center
Protective Spirit Remnant
Both handsFaelan spark bow - became somewhat necessary. Wish there would be a bow with a bigger range that also did the flaming arrows, or that the flaming arrows would actually catch people on fire, but I tried later quests with other bows and this was the only one that worked.
HeadCirclet of the ancient hero - the awesomest
Neck Meirwood charm
Body Meirscale cuirass - helpful against cultists
Arms Runewarded bracers - let's you put out fire on yourself, the best
Ring Ring of mists
WaistR unechain belt
Feet Boots of the wandering tribes
Gloves of spirit's grasp - not actually useful, but creepy and great
Golden platecoat - would be awesome for a Beacon
Warded robe - very useful in early quests